Search on: MITOGEN-ACTIVATED PROTEIN KINASES 
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Descriptor English:   Mitogen-Activated Protein Kinases 
Descriptor Spanish:   Proteínas Quinasas Mitógeno Activadas 
Descriptor Portuguese:   Proteínas Quinases Ativadas por Mitógeno 
Tree Number:   D08.811.913.696.620.682.700.567
D08.811.913.696.620.682.700.646.750
D12.644.360.450
D12.776.476.450
Definition English:   A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES). 
Indexing Annotation English:   DF: ERKS
See Related English:   MAP Kinase Signaling System
 
History Note English:   2000; for EXTRACELLULAR SIGNAL-REGULATED KINASES use CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE 1994-1999 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   34450 
Unique Identifier:   D020928 

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